基于水文要素变化特征的浑河干流生态需水量计算

将浑河干流划分为4个区域进行生态需水量计算.根据浑河干流特点,将其生态需水分为河流基本生态需水、河流稀释自净需水、输沙需水和蒸发需水.根据浑河水文要素变化特征确定各类生态需水量的计算方法,并对各类生态需水进行类型整合.计算结果表明:北口前站全年的生态需水量为0.55×108 m3,抚顺站为9.59×108 m3,沈阳站为6.93×108 m3,邢家窝棚站为10.55×108 m3,并给出了逐月变化,以利于浑河干流水资源优化配置.结合浑河干流水文要素变化特征,对其生态需水量特征进行了分析,并提出相应建议.     

迭代接收下高效链路自适应传输方法

针对3GPP LTE下行传输链路,研究迭代接收情况下的高效链路自适应(LA,Link Adaptation)方法.首先,给出迭代接收后验信干比及等效信噪比的计算方法;然后,利用传统LA方法确定秩指示和信道质量指示的取值范围;接着,提出高效LA方法,该方法仅在秩指示和信道质量指示的范围内确定反馈参数,减少了后验信干比及等效信噪比的计算次数,从而降低了在线吞吐量预测的计算量;最后,仿真结果表明,所提LA方法的吞吐量优于传统LA方法,满足链路服务质量并且获得了3.5 dB吞吐量增益.     

Role of Ppt1 in multiple stress responses in Candida albicans

To study the function of CaPptl, we deleted PPT1 gene from the Candida albicans genome by sequentially replacing the entire coding region with the selectable markers ARG4 and HIS1. The results showed that the deletion of Pptl did not affect the hyphal formation of C. albicans under serum induction and caused enhanced sensitivity to DNA damage, Calcofluor white and salt- induced stress. We also found that Pptl was not required for the phenotypic response of cells treated with the genotoxins, methylmethane sulfonate and hydroxyurea. Flow cytometric analyses indicated that pptlA cells and wild-type cells showed similar G2/M arrest profiles when exposed to DNA damage stress. Pptl was not required for the activation of the DNA damage response pathway, as indicated by normal phosphorylation of Rad53 and Rfa2 in pptlA cells under DNA damage stress. We suggest that Pptl plays important roles in response to various stress conditions in C. albicans.     

Visualization of the complex structure and stress field inside rock by means of 3D printing technology

Accurate characterization and visualization of the complex inner structure and stress distribution of rocks are of vital significance to solve a variety of underground engineering problems. In this paper, we incorporate several advanced technologies, such as CT scan, three-dimensional（3D） reconstruction, and 3D printing, to produce a physical model representing the natural coal rock that inherently contains complex fractures or joints. We employ 3D frozen stress and photoelastic technologies to characterize and visualize the stress distribution within the fractured rock under uniaxial compression. The 3D printed model presents the fracture structures identical to those of the natural prototype. The mechanical properties of the printed model,including uniaxial compression strength, elastic modulus,and Poisson’s ratio, are testified to be similar to those of the prototype coal rock. The frozen stress and photoelastic tests show that the location of stress concentration and the stress gradient around the discontinuous fractures are in good agreement with the numerical predictions of the real coalsample. The proposed method appears to be capable of visually quantifying the influences of discontinuous,irregular fractures on the strength, deformation, and stress concentration of coal rock. The method of incorporating3 D printing and frozen stress technologies shows a promising way to quantify and visualize the complex fracture structures and their influences on 3D stress distribution of underground rocks, which can also be used to verify numerical simulations.     

Dynamic analysis of DNA damage induced miRNAs in colon cancer cells

It is known that microRNAs （miRNAs） expression profile shows substantial changes in cells under DNA damage. Here, we did miRNA microarray and quantitative real-time PCR to comprehensively identify the differentially expressed miRNAs in colon cancer cell lines HCT116 p53＋/＋ and HCT116 p53-/-. Cluster analysis revealed a panel of differentially expressed miRNAs which are regulated by p53 and/or UV-C induced DNA damage. These altered miRNAs tend to be located in chromosomes 13, X and 17. Moreover, pathways enrichment analysis estimated that MAPK pathway, focal adheren pathway, p53 pathway and Wnt pathway were mediated by these miRNAs to exert their functions in DNA damage response. Additionally, we found that miR- 320a, one of the UV-C induced miRNAs, play a role in protecting cells from DNA damage. Taken together, our results show that miRNAs are dynamic regulated in p53- dependent or -independent manners in different cell contexts and different situations following DNA damage.     

The analysis of the Earth co-orbital motion of Chang’e-2 after asteroid flyby

After the Chang’e-2 spacecraft conducted a successful asteroid flyby,where is it flying to in interplanetary space?This question is answered via an introduction to the Chang’e-2’s flight trajectory after asteroid flyby that is termed Earth co-orbital motion.Based on preliminary analysis using the dynamical systems theory,Poincare′sections concept,and routine optimization techniques,it is now predicted that,from the point of view of orbital mechanics,Chang’e-2 is capable of returning to the vicinity of the Earth in no more than 20 a and might be recaptured by the Earth if appropriate orbital maneuvers are going to be exerted,either by itself or by another spacecraft that captures Chang’e-2.     

Research progress in ZnO single-crystal: growth,scientific understanding,and device applications

Zinc oxide, a wide band-gap semiconductor, has shown extensive potential applications in high-efficiency semiconductor photoelectronic devices, semiconductor photocatalysis, and diluted magnetic semiconductors. Due to the undisputed lattice integrity, ZnO single crystals are essential for the fabrication of high-quality ZnO-based photoelectronic devices, and also believed to be ideal research subjects for understanding the underlying mechanisms of semiconductor photocatalysis and diluted magnetic semiconductors. This review, which is organized in two main parts, introduces the recent progress in growth, basic characterization, and device development of ZnO single crystals, and some related works in our group. The first part begins from the growth of ZnO single crystal, and summarizes the fundamental and applied investigations based on ZnO single crystals. These works are composed of the fabrication of homoepitaxial ZnO-based photoelectronic devices, the research on the photocatalysis mechanism, and dilute magnetic mechanism. The second part describes the fabrication of highly thermostable n-type ZnO with high mobility and high electron concentration through intentional doping. More importantly, in this part, a conceptual approach for fabricating highly thermostable p-type ZnO materials with high mobility through an integrated three-step treatment is proposed on the basis of the preliminary research.     

Thermal diffusivity determination of solids by time-domain photoacoustic piezoelectric technique

Thermal–physical property is one of the most important properties of materials. The conventional frequency-domain photoacoustic piezoelectric(PAPE) technique has been developed as an important method for thermal diffusivity determination. In this paper, the PAPE technique is extended to time domain(TD). First, based on a simplified thermoelastic model, the TD PAPE theory under square-wave-modulated excitation was developed,the dependence of the TD PAPE signal on modulation frequency as well as material parameters was obtained, and the determination of thermal diffusivity was simulated and theoretically analyzed. Second, the experimental system and the corresponding measurement method were established. Third, thermal diffusivities of various standard samples, such as copper, aluminum, and nickel, were measured, and the effectiveness of the technique was verified. The results show that the TD PAPE technique can provide a simple, fast and effective way for thermal diffusion study.     

Stable silver nanoparticles–aptamer bioconjugates for cellular prion protein imaging

Combining the unique optical properties of metal nanoparticles and the specific recognition of aptamer,aptamer–nanoparticle conjugates have been extensively used in a wide range of applications,particularly multifunctional nanoparticles for cell detection and molecular imaging.Conventional conjugates prepared by chemisorption of monothiol-modified oligonucleotides onto nanoparticle surfaces suffer from a lack of stability when exposed to a variety of small molecules.If silver is used in place of gold,then this lack of stability is even more pronounced.In this study,we reported here the effective and facile strategy of preparing stable silver nanoparticle–aptamer conjugates by in situ generation of strong metal affinity capping ligands,dithiocarbamates modified anti-prion protein aptamer.The conjugates produced are stable and can withstand NaCl concentration at0.25 mol/L.Meanwhile,they could be applied in the cellular prion protein imaging successfully.     

支持海量数据的分布式数据库架构设计与验证

结合电信行业实际业务需求,利用数据库代理,设计出了能够提供强一致性、高可用性并支持弹性水平扩展能力的分布式数据库架构.验证结果表明,对于分布式数据库采用数据库代理可满足高可用性与弹性水平扩展的设计要求,实际部署中,双Master部署模式性能体现较佳,读写分离的部署模式、读写操作部署在一台设备性能下降明显,说明数据库代理可以实现高可用性的分布式数据库架构,各类部署架构中影响性能的是磁盘I/O.